MBE Advance Access originally published online on April 25, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mol. Biol. Evol. 20(6):893-900. 2003
DOI: 10.1093/molbev/msg092
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038
A Genome Scan to Detect Candidate Regions Influenced by Local Natural Selection in Human Populations
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
As human populations dispersed throughout the world, they were subjected to new selective forces, which must have led to local adaptation via natural selection and hence altered patterns of genetic variation. Yet, there are very few examples known in which such local selection has clearly influenced human genetic variation. A potential approach for detecting local selection is to screen random loci across the genome; those loci that exhibit unusually large genetic distances between human populations are then potential markers of genomic regions under local selection. We investigated this approach by genotyping 332 short tandem repeat (STR) loci in Africans and Europeans and calculating the genetic differentiation for each locus. Patterns of genetic diversity at these loci were consistent with greater variation in Africa and with local selection operating on populations as they moved out of Africa. For 11 loci exhibiting the largest genetic differences, we genotyped an additional STR locus located nearby; the genetic distances for these nearby loci were significantly larger than average. These genomic regions therefore reproducibly exhibit larger genetic distances between populations than the "average" genomic region, consistent with local selection. Our results demonstrate that genome scans are a promising means of identifying candidate regions that have been subjected to local selection.
Key Words: selection • humans • genetic distance • STR
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Yamasaki, S. G. Schroeder, H. Sanchez-Villeda, B. S. Gaut, and M. D. McMullen Empirical Analysis of Selection Screens for Domestication and Improvement Loci in Maize by Extended DNA Sequencing The Plant Genome, July 1, 2008; 1(1): 33 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Innan and Y. Kim Detecting Local Adaptation Using the Joint Sampling of Polymorphism Data in the Parental and Derived Populations Genetics, July 1, 2008; 179(3): 1713 - 1720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hawks, E. T. Wang, G. M. Cochran, H. C. Harpending, and R. K. Moyzis Recent acceleration of human adaptive evolution PNAS, December 26, 2007; 104(52): 20753 - 20758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Kane and L. H. Rieseberg Selective Sweeps Reveal Candidate Genes for Adaptation to Drought and Salt Tolerance in Common Sunflower, Helianthus annuus Genetics, April 1, 2007; 175(4): 1823 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wiehe, V. Nolte, D. Zivkovic, and C. Schlotterer Identification of Selective Sweeps Using a Dynamically Adjusted Number of Linked Microsatellites Genetics, January 1, 2007; 175(1): 207 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Casa, S. E. Mitchell, J. D. Jensen, M. T. Hamblin, A. H. Paterson, C. F. Aquadro, and S. Kresovich Evidence for a Selective Sweep on Chromosome 1 of Cultivated Sorghum Crop Sci., November 1, 2006; 46(Supplement_1): S-27 - S-40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Kelley, J. Madeoy, J. C. Calhoun, W. Swanson, and J. M. Akey Genomic signatures of positive selection in humans and the limits of outlier approaches Genome Res., August 1, 2006; 16(8): 980 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Harr Genomic islands of differentiation between house mouse subspecies Genome Res., June 1, 2006; 16(6): 730 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Teshima, G. Coop, and M. Przeworski How reliable are empirical genomic scans for selective sweeps? Genome Res., June 1, 2006; 16(6): 702 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bonin, P. Taberlet, C. Miaud, and F. Pompanon Explorative Genome Scan to Detect Candidate Loci for Adaptation Along a Gradient of Altitude in the Common Frog (Rana temporaria) Mol. Biol. Evol., April 1, 2006; 23(4): 773 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ihle, I. Ravaoarimanana, M. Thomas, and D. Tautz An Analysis of Signatures of Selective Sweeps in Natural Populations of the House Mouse Mol. Biol. Evol., April 1, 2006; 23(4): 790 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. B. DuMont and C. F. Aquadro Multiple Signatures of Positive Selection Downstream of Notch on the X Chromosome in Drosophila melanogaster Genetics, October 1, 2005; 171(2): 639 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Haddrill, K. R. Thornton, B. Charlesworth, and P. Andolfatto Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations Genome Res., June 1, 2005; 15(6): 790 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vasemagi, J. Nilsson, and C. R. Primmer Expressed Sequence Tag-Linked Microsatellites as a Source of Gene-Associated Polymorphisms for Detecting Signatures of Divergent Selection in Atlantic Salmon (Salmo salar L.) Mol. Biol. Evol., April 1, 2005; 22(4): 1067 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Stajich and M. W. Hahn Disentangling the Effects of Demography and Selection in Human History Mol. Biol. Evol., January 1, 2005; 22(1): 63 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Storz, B. A. Payseur, and M. W. Nachman Genome Scans of DNA Variability in Humans Reveal Evidence for Selective Sweeps Outside of Africa Mol. Biol. Evol., September 1, 2004; 21(9): 1800 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Hammer, D. Garrigan, E. Wood, J. A. Wilder, Z. Mobasher, A. Bigham, J. G. Krenz, and M. W. Nachman Heterogeneous Patterns of Variation Among Multiple Human X-Linked Loci: The Possible Role of Diversity-Reducing Selection in Non-Africans Genetics, August 1, 2004; 167(4): 1841 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fischer, V. Wiebe, S. Paabo, and M. Przeworski Evidence for a Complex Demographic History of Chimpanzees Mol. Biol. Evol., May 1, 2004; 21(5): 799 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Campbell and L. Bernatchez Generic Scan Using AFLP Markers as a Means to Assess the Role of Directional Selection in the Divergence of Sympatric Whitefish Ecotypes Mol. Biol. Evol., May 1, 2004; 21(5): 945 - 956. [Abstract] [Full Text] [PDF]
|
|