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Molecular Biology and Evolution, Vol 12, 163-167, Copyright © 1995 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Four-cluster analysis: a simple method to test phylogenetic hypotheses

A Rzhetsky, S Kumar and M Nei
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802.

A simple statistical test for comparing three alternative phylogenetic hypotheses for four monophyletic groups is presented. This test is based on the minimum-evolution principle, and it does not require any information regarding the branching order within each monophyletic group. It is computationally efficient and can be easily extended to five or more monophyletic groups.
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