Molecular Biology and Evolution, Vol 16, 826-838, Copyright © 1999 by Society for Molecular Biology and Evolution
J Chiu, R DeSalle, HM Lam, L Meisel and G Coruzzi
We performed a genealogical analysis of the ionotropic glutamate receptor
(iGluR) gene family, which includes the animal iGluRs and the newly
isolated glutamate receptor-like genes (GLR) of plants discovered in
Arabidopsis. Distance measures firmly placed the plant GLR genes within the
iGluR clade as opposed to other ion channel clades and indicated that
iGluRs may be a primitive signaling mechanism that predated the divergence
of animals and plants. Moreover, phylogenetic analyses using both parsimony
and neighbor joining indicated that the divergence of animal iGluRs and
plant GLR genes predated the divergence of iGluR subtypes (NMDA vs.
AMPA/KA) in animals. By estimating the congruence of the various glutamate
receptor gene regions, we showed that the different functional domains,
including the two ligand-binding domains and the transmembrane regions,
have coevolved, suggesting that they assembled together before plants and
animals diverged. Based on residue conservation and divergence as well as
positions of residues with respect to functional domains of iGluR proteins,
we attempted to examine structure-function relationships. This analysis
defined M3 as the most highly conserved transmembrane domain and identified
potential functionally important conserved residues whose function can be
examined in future studies.
ORIGINAL ARTICLE
Molecular evolution of glutamate receptors: a primitive signaling mechanism that existed before plants and animals diverged
Department of Biology, New York University, New York 10003, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Sarkar, R. DeSalle, and P. B. Fisher Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting PNAS, November 4, 2008; 105(44): 17040 - 17045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Stephens, Z. Qi, and E. P. Spalding Glutamate Receptor Subtypes Evidenced by Differences in Desensitization and Dependence on the GLR3.3 and GLR3.4 Genes Plant Physiology, February 1, 2008; 146(2): 529 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Forde and P. J. Lea Glutamate in plants: metabolism, regulation, and signalling J. Exp. Bot., July 1, 2007; 58(9): 2339 - 2358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Qi, N. R. Stephens, and E. P. Spalding Calcium Entry Mediated by GLR3.3, an Arabidopsis Glutamate Receptor with a Broad Agonist Profile Plant Physiology, November 1, 2006; 142(3): 963 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ben-Shlomo and A. J. W. Hsueh Three's Company: Two or More Unrelated Receptors Pair with the Same Ligand Mol. Endocrinol., May 1, 2005; 19(5): 1097 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nagata, S. Iizumi, K. Satoh, H. Ooka, J. Kawai, P. Carninci, Y. Hayashizaki, Y. Otomo, K. Murakami, K. Matsubara, et al. Comparative Analysis of Plant and Animal Calcium Signal Transduction Element Using Plant Full-Length cDNA Data Mol. Biol. Evol., October 1, 2004; 21(10): 1855 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sivaguru, S. Pike, W. Gassmann, and T. I. Baskin Aluminum Rapidly Depolymerizes Cortical Microtubules and Depolarizes the Plasma Membrane: Evidence that these Responses are Mediated by a Glutamate Receptor Plant Cell Physiol., July 15, 2003; 44(7): 667 - 675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kang and F. J. Turano The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana PNAS, May 27, 2003; 100(11): 6872 - 6877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. DAVENPORT Glutamate Receptors in Plants Ann. Bot., November 1, 2002; 90(5): 549 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Schultz Shared Signals and the Potential for Phylogenetic Espionage Between Plants and Animals Integr. Comp. Biol., July 1, 2002; 42(3): 454 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Chiu, E. D. Brenner, R. DeSalle, M. N. Nitabach, T. C. Holmes, and G. M. Coruzzi Phylogenetic and Expression Analysis of the Glutamate-Receptor-Like Gene Family in Arabidopsis thaliana Mol. Biol. Evol., July 1, 2002; 19(7): 1066 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Minorsky Plant Physiology, March 1, 2002; 128(3): 788 - 789. [Full Text] [PDF]
|
|
|
|
|
|
D. C. Daly, K. M. Cameron, and D. W. Stevenson Plant Systematics in the Age of Genomics Plant Physiology, December 1, 2001; 127(4): 1328 - 1333. [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Eckardt, H.-T. Cho, R. M. Perrin, and M. R. Willmann Plant Biology 2001 PLANT CELL, October 1, 2001; 13(10): 2165 - 2173. [Full Text] [PDF]
|
|
|
|
|
|
F. J. Turano, G. R. Panta, M. W. Allard, and P. van Berkum The Putative Glutamate Receptors from Plants Are Related to Two Superfamilies of Animal Neurotransmitter Receptors via Distinct Evolutionary Mechanisms Mol. Biol. Evol., July 1, 2001; 18(7): 1417 - 1420. [Full Text] [PDF]
|
|
|
|
|
|
M. Nars and M. Vihinen Coevolution of the Domains of Cytoplasmic Tyrosine Kinases Mol. Biol. Evol., March 1, 2001; 18(3): 312 - 321. [Abstract] [Full Text]
|
|
|
|
|
|
K. L. Dennison and E. P. Spalding Glutamate-Gated Calcium Fluxes in Arabidopsis Plant Physiology, December 1, 2000; 124(4): 1511 - 1514. [Full Text]
|
|
|
|
|
|
E. D. Brenner, N. Martinez-Barboza, A. P. Clark, Q. S. Liang, D. W. Stevenson, and G. M. Coruzzi Arabidopsis Mutants Resistant to S(+)-{beta}-Methyl-{alpha}, {beta}-Diaminopropionic Acid, a Cycad-Derived Glutamate Receptor Agonist Plant Physiology, December 1, 2000; 124(4): 1615 - 1624. [Abstract] [Full Text]
|
|