Molecular Biology and Evolution, Vol 10, 823-841, Copyright © 1993 by Society for Molecular Biology and Evolution
C Zapata and G Alvarez
The capacity to detect nonrandom associations between restriction-map
variants was examined in eight gene regions of Drosophila melanogaster
(yellow-achaetescute, white, Zw, Adh, Est6, and rosy) and D. pseudoobscura
(Adh and Xdh), on the basis of published population data. The statistical
power from individual pairwise tests was both heterogeneous and generally
low across gene regions. Sample sizes larger than those currently being
used are needed to ensure any power to detect disequilibrium by individual
tests. It is found that the heterogeneity in power is mostly explained by
large differences in the intensity of sample disequilibrium among regions.
The yellow-achaete- scute, Zw, and Adh loci of D. melanogaster displayed
both the highest mean power (approximately 0.4) and a very great
disequilibrium (mean absolute values of D' were 0.8-1). By contrast, all
the other gene regions exhibited lower mean power (approximately 0.2) and
moderate levels of disequilibrium (0.4-0.6). Although the proportion of
significant pairwise associations, especially for white, Est6, and rosy in
D. melanogaster and for Adh and Xdh in D. pseudoobscura, is more or less
close to the type I error, simultaneous-inference significance tests show
that gametic disequilibrium is occurring at the eight DNA regions examined.
ORIGINAL ARTICLE
On the detection of nonrandom associations between DNA polymorphisms in natural populations of Drosophila
Museum of Comparative Zoology, Harvard University.
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